Intake of Vitamin 'C' is Helpful in Reducing Risk of Blood Cancer

Vitamin C is an essential nutrient involved in the repair of tissue, Normal doses are safe during pregnancy, Foods that contain vitamin C include.

In 1912 Vitamin C was discovered and isolated in 1928, and first made in 1933. It is on the World Health Organization’s List of Essential Medicines, the most effective and safe medicines needed in a health system.

Vitamin C is available as a generic medication and over the counter. In 2015, the wholesale cost in the developing world was about 0.003 to 0.007 USD per tablet.

An important water-soluble, Vitamin C is helps the body form and maintain connective tissue such as bones, blood vessels and skin, another name of Vitamin C is ascorbic acid and L-ascorbic acid, is a vitamin found in food and used as a dietary supplement. As a supplement it is used to treat and prevent scurvy.

It is generally well tolerated. Large doses may cause gastrointestinal discomfort, headache, trouble sleeping, and flushing of the skin. Evidence does not support use in the general population for the prevention of the common cold, It may be taken by mouth or by injection.

As per a study published in the journal Nature, boosting daily obligation of vitamin C may be helpful in curbing the development of blood cancer or leukemia. Previous studies have shown that people with lower levels of ascorbate or vitamin C content are at a greater than before cancer risk; however, the reasons are still not fully understood.

In stem cells the body soaked up strangely high levels of vitamin C as per the lessons, which then regulates the cell function and suppresses the development of blood cancer.

“The epigenome is a set of mechanism inside a cell that regulates which genes turn on and turn off, the epigenome can become damaged in a way that increases stem cell function but also increases the risk of leukemia, when the stem cells don’t take delivery of enough vitamin C,” Agathocleous added.

“Stem cells use ascorbate to regulate the abundance of certain chemical modifications on DNA, which are part of the epigenome,” explained Michalis Agathocleous, from University of Texas Southwestern Medical Centre.

The findings have implications for aged patients with a common pre-cancerous condition known as clonal hematopoiesis that puts the patients at an increased risk of developing leukemia.

“Among all the most common mutations in patients with clonal hematopoiesis is a loss of one copy of Tet2. As per the situation the patients get 100 per cent of their daily Vitamin C obligation with clonal hematopoiesis and a Tet2 alteration in a particularly careful way,” said Sean Morrison, Director at the varsity.

Adding vitamin C to your daily diet can help get rid of various ailments? Include oranges, lemon, red peppers, kale, broccoli, grapefruit, guava, papaya, strawberries and tomatoes among others. A study claims that even a deadly blood vitamin C’s High doses may halt the progression of cancer by encouraging faulty stem cells in the bone marrow to die.

An enzyme with few genetic changes for reducing the ability of it are known called TET2 to encourage stem cells to become mature blood cells, which eventually die, in many patients with certain kinds of leukaemia, researchers said.

Benjamin Neel professor at New York University (NYU) in the US said “We are excited by the prospect that high-dose vitamin C might become a safe treatment for blood diseases caused by TET2-deficient leukaemia stem cells, most likely in combination with other under attack therapy”

TET2 function are found in 10 per cent of patients that changes in the genetic code (mutations) and reduces the acute myeloid leukaemia (AML), 30 per cent of those with a form of pre-leukaemia called myelodysplastic syndrome, and in nearly 50 per cent of patients with chronic myelomonocytic leukaemia. Such cancers cause:

  •        Anemia
  •        Infection risk
  •        Bleeding

The relationship between TET2 and cytosine, was studied by the researchers as one of the four nucleic acid “letters” that comprise the DNA code in genes.

To determine the effect of mutations that reduce TET2 function in abnormal stem cells, the team genetically engineered mice such that the scientists could switch the TET2 gene on or off.

They found that similar to the naturally occurring effects of TET2 mutations in mice or humans, using molecular biology techniques to turn off TET2 in mice caused abnormal stem cell behavior. When TET2 expression was restored by a genetic trick these changes were reversed.

Earlier researches had shown that vitamin C could stimulate the activity of TET2 and its relatives TET1 and TET3. In each stem cell is usually affected in TET2-mutant blood diseases only one of the two copies of the TET2 gene is in, as per researchers hypothesised that the high doses of vitamin C, which can only be given intravenously, might reverse the effects of TET2 deficiency by turning up the action of the remaining functional gene.

Restoring TET2 function genetically is has been found that vitamin C did the same thing and by promoting DNA demethylation, high-dose vitamin C treatment induced stem cells to mature, and also suppress the growth of leukaemia cancer stem cells from human patients implanted in mice.

Luisa Cimmino, assistant professor at NYU Langone Health, said that “It has been found that vitamin C treatment had an effect on leukemic stem cells that resembled damage to their DNA.”

In a drug type known to cause cancer cell death by blocking the repair of DNA damage, Researchers combined vitamin C with a PARP inhibitor. They found that the combination had an enhanced effect on leukaemia stem cells, further shifting them from self-renewal back toward maturity and cell death.

Without TET2 mutations Vitamin C might drive leukemic stem cells toward death, given that it turns up any TET2 activity normally in place, Cimmino said.

Vitamin C is abundant in vegetables and fruits. A water-soluble vitamin and powerful antioxidant, it helps the body form and maintain connective tissue, including bones, blood vessels, and skin.

To repair and regenerate tissues, protect against heart disease, aid in the absorption of iron, prevent scurvy, and decrease total and LDL (“bad”) cholesterol and triglycerides Vitamin C helps in all. Supplemental vitamin C may also lessen the duration and symptoms of a common cold, help delay or prevent cataracts, and support healthy immune function.

What are the signs of a vitamin C deficiency?

Deficiency symptoms include the following

  •        Fatigue
  •        Muscle weakness
  •        Joint and muscle aches
  •        Bleeding gums
  •        Leg rashes

Expanded deficiency can cause scurvy, a rare but potentially severe illness.

How much, and what kind, does an adult need?

According to the National Institutes of Health (NIH), the recommended vitamin C daily allowance (RDA) for adults over age 19 is:

  •         men, 90 mg per day
  •         women, 75 mg per day
  •         pregnant women, 85 mg per day
  •         Breastfeeding women, 120 mg per day.

Dr. Weil recommends taking 250 mg of vitamin C each day. Smokers may benefit from a higher intake.

How much does a child need?

NIH recommends Adequate Intakes (AIs):

  •         infants 0-6 months old, 40 mg per day
  •         infants 7-12 months old, 50 mg per day.

The RDAs of vitamin C for teens and children are:

  •         toddlers 1-3 years old, 15 mg per day
  •         children 4-8 years old, 25 mg per day
  •         children 9-13 years old, 45 mg per day
  •         male teens 14-18 years old, 75 mg per day
  •         65 mg per day for female teens 14-18 years old.

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